Detroit Lions NFL Week 3 continues with a thrilling matchup between the Detroit Lions and the Arizona Cardinals at State Farm Stadium this Sunday. Both teams enter with a 1-1 record, holding second place in their respective divisions. The Lions will be eager to rebound after a narrow loss to the Buccaneers, while the Cardinals are riding high following a dominant victory over the Rams. Here’s a breakdown of the odds, key players, and predictions for this exciting NFC clash.
Game Preview: Lions vs. Cardinals
Date: Sunday, September 22
Time: 4:25 p.m. ET
Location: State Farm Stadium, Glendale, Arizona
Betting Odds and Lines
Moneyline: Detroit Lions (-150) vs. Arizona Cardinals (+125)
Spread: Detroit Lions (-3) vs. Arizona Cardinals (+3)
Total (O/U): Detroit Lions (u51.5) vs. Arizona Cardinals (o51.5)
Detroit Lions: Looking to Bounce Back
The Lions struggled in Week 2, falling 20-16 to the Buccaneers despite strong efforts from quarterback Jared Goff and running back Jahmyr Gibbs. Goff threw for 307 yards, but a pair of interceptions stunted the Lions’ offense. Gibbs put up 84 rushing yards, and Amon-Ra St. Brown had a standout game with 119 receiving yards, but it wasn’t enough to secure the win.
Key Players:
Jared Goff: 524 yards, 1 TD, 3 INT
David Montgomery: 28 carries, 126 yards, 2 TD
Jameson Williams: 10 receptions, 200 yards, 1 TD
Arizona Cardinals: Riding High After Week 2
The Cardinals impressed in their Week 2 matchup, thrashing the Rams 41-10. Kyler Murray was nearly perfect, throwing for 266 yards and 3 touchdowns. Running back James Conner dominated the ground game with 122 rushing yards and a touchdown, while wide receiver Marvin Harrison Jr. racked up 130 receiving yards and two scores.
Key Players:
Kyler Murray: 428 yards, 4 TD, 0 INT
James Conner: 37 carries, 172 yards, 2 TD
Marvin Harrison Jr.: 5 receptions, 134 yards, 2 TD
Lions vs. Cardinals Injury Report
Detroit Lions: The Lions will be missing key players, including LB Alex Anzalone (concussion) and DE Marcus Davenport (groin). WR Amon-Ra St. Brown is probable to play, which should provide a boost to their offense.
Arizona Cardinals: LB BJ Ojulari and DT Darius Robinson are out with knee and calf injuries, respectively, while WR Xavier Weaver remains questionable with an oblique injury.
Betting Trends
The Lions are 7-2 against the spread (ATS) in their last 9 games and 5-1 ATS in their last 6 on the road.
The Cardinals are 4-1 ATS in their last 5 games and have hit the over in 8 of their last 9 home games.
Game Prediction
While the Lions will be eager to put their Week 2 loss behind them, the Cardinals seem to be in better form, especially after their dominant win against the Rams. With Kyler Murray playing at a high level and the Cardinals’ offense clicking, Arizona is predicted to edge out Detroit in a closely contested matchup.
Final Score Prediction: Arizona Cardinals 25, Detroit Lions 22